- Research Program Mentor
PhD Doctor of Philosophy candidate
Molecular biology, biochemistry and microbiology
Understanding host-pathogen interactions
Intracellular pathogens, such as bacteria and viruses, infect cells of their host as part of their lifecycle. They must also be able to adapt and manipulate their host in favor of their own survival. This begins at the initial step of a pathogen binding to the outer membrane of the cellular host. This is a crucial step as the pathogen must adapt so that it can both successfully enter the host without triggering the defence mechanism and also be specific enough to infect the cell it can replicate in. Once the pathogen enters, it must make more copies of itself to complete the lifecycle while simultaneously acquiring all the essential nutrients and building blocks. It is also fighting against the host to keep the defence system at bay. All pathogens have different approaches to how they interact with their host to ultimately make more copies of itself at every step of its lifecycle. In this project, you will write a scientific review detailing how a pathogen of your choice interacts and manipulates their cellular host to complete its life-cycle. You will learn how to read scientific literature, identify gaps in research, and write a science article. In addition you will learn various concepts of microbiology and cellular biology, specifically in the topic of host-pathogen interactions. I will guide you through every step of the project, including understanding the biology that you may not be familiar with.