How can sleep disturbances progress alpha-synuclein aggregation?

Started Feb. 4, 2022

Abstract or project description

The glymphatic system is a complex network of paravascular channels that delivers nutrients and clears cellular waste products through circulation of cerebrospinal fluid (CSF) and interstitial fluid (ISF). Some cellular waste products include proteins that may contribute to neurodegenerative diseases when they aggregate abnormally. An example of this is alpha-synucleinopathies, which involves accumulation of alpha synuclein protein in the brain, often causing clinical syndromes such as Lewy body dementia and Parkinson’s disease. REM sleep behavior disorder is a hallmark symptom of alpha-synucleinopathies and a frequent treatment target. However, there is evidence that disruptions in non-REM sleep may hinder glymphatic system function and contribute to alpha-synuclein build-up and disease progression. This review will detail non-REM sleep and glymphatic system clearance, including how studies in this area may help future patients be treated for alpha-synucleinopathy symptoms.