2,893 Inspirational Research Project Ideas

Turn inspirations into your passion project.

This collection of project ideas, shared by Polygence mentors, is meant to help inspire student thinking about their own project. Students are in the driver seat of their research and are free to use any or none of the ideas shared by their mentors.

Specific Aims Page

For a given hypothesis, we will work to craft a specific aims page detailing the experiments needed to support or disprove the hypothesis. We will focus on experimental flow, anticipating setbacks, and experimental design.

Cancer, Biotech, Engineering

Ashley
Ashley

Investigating Mechanisms of Action of Potential Antibiotics

We know that antibiotics kill harmful bacteria that make us sick, but how exactly do the antibiotics that we take actually enter and bind to cellular targets, stopping infection? Why does a certain antibiotic kill certain types of bacteria, but not others? Through a genetic engineering approach, we can investigate how many antibiotics are responsible for killing certain types of bacteria.

Biology, Chemistry

Drew
Drew

Build a machine learning model to predict protein levels from gene sequence

If I give you the DNA sequence of a gene, can you predict how much protein that gene produces? So far, even state-of-the-art biological models cannot predict how much protein a given gene will produce. However, with modern machine learning methods, we can produce models that work decently well, most of the time. Machine learning is used across all of science, and can be relatively simple to understand and analyze! We can work together to generate data sets with gene sequences and collect existing data on gene expression, and then experiment with different machine learning models to see which ones best predict gene output from gene sequence.

Biotech

Julian
Julian

Understand the Stock Market

Personal finance is one of the most important skills a young adult can learn. Together, we will put together a "Best Practices: Stock Market in X Industry". We will go over major vocabulary principals, how the stock market works, and choose certain areas to dive deep on (Discounted Cash Flow, Options, Stock Splits).

Business, Engineering, Languages

Cathy
Cathy

Case Study Reporting on Rare Diseases

Case reports and case series or rather case study research are descriptive studies that are prepared for illustrating novel, unusual, or atypical features identified in patients in medical practice, and they potentially generate new research questions. They are empirical inquiries or investigations of a patient or a group of patients in a natural, real world clinical setting. Case study research is a method that focuses on the contextual analysis of a number of events or conditions and their relationships. Case research is a beneficial tool and learning experience in graduate medical education and among novice researchers. Rare disease patients have cases that extremely unique to the medical field due to frequency, hidden states, and lack of knowledge by medical & research professionals. By creating a case report for a certain kind of rare disease, we could help with the diagnosis and the mitigation of rare diseases, which heavily occur in young children at high mortality rates.

Biology, Physics, Comp Sci

Darrell
Darrell

Applying Privacy in AI

Privacy is normally a vague concept, but there are techniques to measure it in a rigorous way. Furthermore, there are ways of training AI models that preserve privacy - this is becoming an interesting area of research.

Engineering, Comp Sci, AI/ML

Efthimios
Efthimios

CRISPR as a therapeutic intervention

Demonstrate an in-depth understanding of the molecular basis of CRISPR and the strengths and limitations of the technology by proposing and designing a CRISPR therapeutic for a genetic disorder.

Biology, Neuroscience, Engineering

Olivia
Olivia

Fake News Detector

The system should provide each of the following functionalities: Scrape news articles and fake news datasets from the web Wrangle data from various sources into a unified structure Labelling interface to enable a workforce to label newly scraped articles Extract linguistic features from the scraped articles Model support including training, validation, hyper-parameter tuning, and hosting Online model experimentation Extensive Logging

Engineering, AI/ML

Rahul
Rahul

An IoT-powered Framework to Assist Mission Control

First responders and military members risk their lives for us. However, I personally witnessed in several occasions that their mission control operations are done using a white-board. I believe this is not a sufficient method, and a more advanced method is required. Therefore, I propose wearable modules powered by the long-range wireless tool named Sigfox that ranges around a couple of kilometers. The wearable modules will have sensors, such as GPS, and vital health information. First responder information will be transmitted to a mobile application that will display each unit's location on the map and their health status. Currently, there are two startups working in this area, and I believe they're making a very positive impact.

Business, Engineering, Comp Sci

Berkay
Berkay

Identifying temporal trends in online hate speech

Use topic modeling methods to extract the themes present in hate speech on twitter, and analyze how those themes change over time. Identify offline events that correspond to spikes in different types of hate speech.

Engineering, Comp Sci, AI/ML

Barbara
Barbara

Education Gone Viral!

Produce a multimedia article about how viruses work - the article could include animations or stop motion videos or drawings, plus an explanation about the ways viruses function and an explanation of current virus research.

Biology, Ethics, Cancer, Biotech

Nina
Nina

Lithium Ion Batteries - friend or foe to the environment?

In the next 10 years, millions of electric car batteries will retire. Ever wonder what will happen to them? From production to disposal - Lithium has a journey that is riddled with a lot of challenges. Are these batteries really helping or in fact harming the environment - by negating the 'electric vehicle advantage' for the consumer? This project could explore (as a literary review article or as a research paper) the lifecycle of the super popular Lithium Ion batteries that power the EV cars and their effect on the environment.

Physics, Engineering

Silpa
Silpa

A survey on acceptability of vaccines among millennials

The goal of this project is to familiarize the student with the following skillsets: 1- How to design a survey based on a scientific question 2- How to identify the responders and expand outreach 3- How to analyze results of the survey. Results of this project can be published in a scientific magazine, LinkedIn article, or similar outlets. Reference for the image: https://www.vectorstock.com/royalty-free-vector/medical-survey-line-icon-hospital-patient-history-vector-23114522

Business, Biotech, Engineering, Literature and Languages, AI/ML

Morteza
Morteza

Develop MATLAB/Python code to visualize trajectories of satellites

Based on the equations of motion for objects in space, we can visualize the motion in MATLAB/Python. This requires knowledge of conic sections and the coding environment, however it gives deep insight into how forces work and their mathematical interpretation can lead to actual simulation.

Math, Physics, Engineering

Adarsh
Adarsh

Circuit Fundamentals

Ever look inside a computer or remote control and wonder what those tiny, complex plastic and metal pieces do? They actually form circuits which facilitate the transfer of electrons to the correct places to control your devices! Here you can learn about the fundamentals of current, resistance, and voltage and how to design a circuit to create a calculator or radio. Going further, you can translate your circuit diagram into a physical circuit and manufacture your own functional printed circuit board (PCB).

Neuroscience, Engineering

Madison
Madison

Solar-powered Refrigeration System for Ice Production

The project aims to analyze and design a solar-powered refrigeration system where ice production is used as a case study. The methodology includes studying two parts: refrigeration and solar systems. The refrigeration part is the vapor compression refrigeration system (VCRS) while the solar part is a Photo-voltaic (PV) system. Initially, the refrigeration system is static where no fan is needed, therefore a power input is required to only operate the compressor in the VCRS in order to withstand the refrigeration load to produce 35 kg of ice per day assuming 7 hours of sunshine. For the VCRS, refrigerant R-134a is opted for its availability, low cost, and no-depleting ozone gas.

Engineering

Ahmed
Ahmed

AI - Combining Vision and Language

Big news was made recently in an AI model that can generate images if you give it text. It is called DALL-E 2, and I'm friends with some of the scientists who built it. I also have access to the model as a researcher, and it is a lot of fun to play with! https://youtu.be/qTgPSKKjfVg It would be interesting to make a toy version of this model to better understand how it works!

Engineering, Comp Sci, AI/ML

Efthimios
Efthimios

Advances in cell-based cancer therapeutics

Cell-based therapeutics are a fast-growing area of potential cancer treatments. Here, we compile work from several research labs to provide a review of current advances and trends in the field.

Biology, Cancer, Engineering

Monika
Monika

Microcontroller Exploration and Embedded Systems

Microcontrollers are the heart of modern technology. They live inside everything from giant servers to smart devices. In this project, you will gain exposure to microcontrollers and embedded systems. You will learn about the various hardware and components in the systems, programming models, applications, wireless protocols (Bluetooth, ZigBee, etc.), and more. The final product will be either (1) a complete design project using microcontrollers (robot car. smart lock, etc.) or (2) a thesis-style report describing an application case study. Requirements: - Exposure to basic coding skills is helpful. - May need to purchase materials ($50-100 for electronics, up to the student) - Excitement to learn about a broad technology application!

Engineering, Comp Sci

Bob
Bob

Mechanical testing of various knit architectures

Students will understand the differences between knit architectures and relate these architectures to knit patterns. Students will learn the basics of mechanical/structural testing and understand mechanical property evaluation. Students will gain experience in designing experiments. Students will have the option to extend their study to pattern optimization.

Physics, Engineering, Fluid Dynamics

Hannah
Hannah