Polypilot product mascot

Introducing PolyPilot:

Our AI-Powered Mentorship Program

Start your trial today

Learn More
Go to Polygence Scholars page
Emel Çırakoğlu's cover illustration
Polygence Scholar2023
Emel Çırakoğlu's profile

Emel Çırakoğlu

Class of 2022Ankara, Ankara


**Hi! My name is Emel. My project is about biomarkers that can detect MS in early stages and gene therapies that can be used as a treatment approach in the future.**

Project Portfolio

Gene Therapy With CRISPR-Cas9 To Treat Multiple Sclerosis

Started June 20, 2023

Portfolio item's cover image

Abstract or project description

Multiple Sclerosis (MS) is a chronic immune-mediated neurodegenerative disease leading to progressive demyelination and atrophy in the brain. This project aims to first briefly highlight immune mediators of the disease, especially regulatory T cells (Tregs). The project will then discuss biomarkers associated with MS, focusing on those expressed by Tregs. Subsequently, the CRISPR-Cas9 system and how it targets genes for deletion, insertion, or replacement will be described. The final part of the project will discuss different targets and delivery methods for CRISPR-Cas9 therapy for MS.