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Polygence Scholar2022
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Claire Loftus

Mayo High SchoolClass of 2025Rochester, Minnesota


Hello! My name is Claire and my Polygence project is on applying immunotherapies to treat Acute Lymphoblastic Leukemia (ALL). I chose to work on this project because I am interested in pediatric oncology and I wanted to learn more about upcoming treatments for ALL. After my project is complete, I would like to publish my article and potentially create my own website.


  • "Immunotherapies for Acute Lymphoblastic Leukemia" with mentor Carlos (Aug. 12, 2022)

Project Portfolio

Immunotherapies for Acute Lymphoblastic Leukemia

Started Mar. 9, 2022

Portfolio item's cover image

Abstract or project description

Acute lymphoblastic leukemia is a rapidly progressing cancer in which the stem cells within the bone marrow differentiate into immature lymphocytes and proliferate from there. More specifically there is an overproduction of immature lymphocytes that in turn causes a deficiency in the other blood cell types leading patients to become immunocompromised, anemic, or thrombocytopenic. Traditionally this type of cancer has been treated with chemotherapy or radiation. Although these traditional methods may be successful most of the time, they can also come with harmful side effects, but new advanced treatments have been developed in the form of immunotherapies. Some of these latest immunotherapies include CAR-T therapy, monoclonal antibodies, allogeneic transplantation, and checkpoint inhibitor drugs which are an improvement from previous methods because they target specific regions of the body and utilize the body's immune system. Through this project I aim to provide insights into how these immunotherapies function and why they are useful for treating ALL.