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Immunotherapies for Acute Lymphoblastic Leukemia

Claire
Claire
Hello! My name is Claire and my Polygence project is on applying immunotherapies to treat Acute Lymphoblastic Leukemia (ALL). I chose to work on this project because I am interested in pediatric oncology and I wanted to learn more about upcoming treatments for ALL. After my project is complete, I would like to publish my article and potentially create my own website.
High School
Mayo High School
Graduation Year
2025
Student review
The mentor that I worked with exceeded my expectations.

View Polygence scholar page
Project description

Acute lymphoblastic leukemia is a rapidly progressing cancer in which the stem cells within the bone marrow differentiate into immature lymphocytes and proliferate from there. More specifically, there is an overproduction of immature lymphocytes that in turn causes a deficiency in the other blood cell types leading patients to become immunocompromised, anemic, or thrombocytopenic. Traditionally, this type of cancer has been treated with chemotherapy or radiation. Although these traditional methods may be successful most of the time, they can also come with harmful side effects, but new advanced treatments have been developed in the form of immunotherapies. Some of these latest immunotherapies include CAR-T therapy, monoclonal antibodies, allogeneic transplantation, and checkpoint inhibitor drugs which are an improvement from previous methods because they target specific regions of the body and utilize the body's immune system. Through this project, I aimed to provide insights into how these immunotherapies function and why they are useful for treating ALL.

Immunotherapies for Acute Lymphoblastic Leukemia
Project outcome

I created a review article and presented at The Symposium of Rising Scholars.


Carlos
Carlos
Doctor of Philosophy candidate
Subjects
Immunology, Cancer, Cellular and Molecular
Expertise
Cancer Biology, Immunology, Molecular Biology
Mentor review

Despite the fact that I did not know a lot about my topic, he made sure I fully understood all of the material and thoroughly answered any questions I had. Furthermore, whenever I messaged him, he answered in a timely answer. Lastly, he gave me helpful tips while still emphasizing the fact that it is my article.