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What are the genetic and environmental contributors to depression, and how can these influence treatment options?

Project by Polygence alum Saara

What are the genetic and environmental contributors to depression, and how can these influence treatment options?

Project's result

I created a research paper and have submitted my paper for publication to the Journal of High School Science.

They started it from zero. Are you ready to level up with us?

Summary

Depression is a mental illness with the highest prevalence worldwide, and a large percentage of individuals will have depression symptoms at some point in their lives. This paper will examine genetic and environmental contributors to depression and consider how this information can be used to develop more effective treatments. In particular, genetic contributions will be informed by genome-wide association studies that identify gene variants likely to be involved in depression, as well as several pathways by which depression can modulate brain morphology. The paper will also consider the interplay between genetics and environmental stimuli like trauma or social stress, and discuss how genetic variation may contribute to the propensity of an individual to develop depression. Finally, the paper will consider how antidepressant medications can be prescribed on the basis of genetic/environmental information in order to yield an individualized and more effective treatment strategy.

Jacob

Jacob

Polygence mentor

PhD Doctor of Philosophy candidate

Subjects

Medicine, Biology

Expertise

Biology, Biochemistry, Genetics, Bioethics

Saara

Saara

Student

Graduation Year

2023

Project review

“I believed, I would be on my own for most of the project but my mentor was helpful throughout the whole process; so, the mentorship really exceeded my expectations.”

About my mentor

“My mentor was helpful throughout the whole process. He helped me in finding the resources, understanding the topics properly, correcting mistakes in my paper, and finding journals right for my paper. I am extremely thankful to him.”