Sravya Damarla

Which cell types, other than keratinocytes, are involved and how do they function in controlling the phenotypic switch of psoriasis to atopic dermatitis?

Started July 30, 2024

Abstract or project description

Clinical observations have revealed that patients undergoing treatment for psoriasis may experience a phenotypic switch towards atopic dermatitis (AD), suggesting that these conditions may represent a broader spectrum of inflammatory skin diseases. Extensive research has established the response of keratinocytes to cytokines in both psoriasis and AD, resulting in altered proliferation and differentiation, but emerging evidence suggests that other cell types could also significantly influence this transition. This study aims to examine current research on non-keratinocyte cell groups, for instance various T cell subsets, dendritic cells, and other inflammatory mediators, and their contributions to the phenotypic switch from psoriasis to AD. This analysis will utilize findings from both experimental and clinical studies to explore the complex cellular relationships and cytokine signaling pathways that could underlie this process. Highlighting the potential shared mechanisms across inflammatory skin diseases may elucidate promising paths to develop targeted therapeutic strategies aimed at diminishing the phenotypic shift.