Symposium

Of Rising Scholars

Spring 2024

Sonya will be presenting at The Symposium of Rising Scholars on Saturday, March 23rd! To attend the event and see Sonya's presentation.

Go to Polygence Scholars page
Sonya Sar's cover illustration
Polygence Scholar2023
Sonya Sar's profile

Sonya Sar

Class of 2025San Jose, California

Project Portfolio

Analysis of the Therapeutic Strategies Used to Treat ALS Caused by TDP-43 Aggregation

Started Apr. 14, 2023

Portfolio item's cover image

Abstract or project description

Amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder that impairs motor functions, affects 1 in 50,000 people in the world, and almost 90% of patients diagnosed do not have any family history of the disease. ALS is a debilitating disease due to the limited effectiveness of treatments for most patients. However, researchers were able to identify one protein that malfunctions in almost 97% of patients: TDP-43. TDP-43 is a protein that regulates the process of transcription, and it is known to aggregate in the neurons of patients with ALS. Many researchers have decided to focus their therapeutic strategies on the protein aggregation using genetic therapies on small molecules. This study focuses on analyzing the benefits and limitations of the therapeutic strategies used to treat ALS caused by TDP-43 aggregation and identifying which method holds the most promise to target this proteinopathy.