Northwood HighClass of 2025Irvine, California
AboutHi! My name is Snigdha and my Polygence project is a research paper that explores whether or not there is a correlation between TGF-β1 mutations in animals with short lifespans and with human cancer. My paper identifies possible mutations that can cause the tumor supressor to turm proto-oncogenic and then compares them with lnown mutations found in humans.
- "How can the different regulations of TGF-β1 affect the tumor-microenvironment, both positively and negatively?" with mentor Max (Dec. 23, 2022)
How can the different regulations of TGF-β1 affect the tumor-microenvironment, both positively and negatively?
Started July 26, 2022
Abstract or project description
TGF-beta1, a growth factor protein, affects numerous cellular signaling and responses. Through ligand binding, the activation of serine/threonine, Smad proteins, and VEGF proteins is vital in the tumor-microenvironment. By regulating apoptosis and granulation, and inhibiting cellular proliferation and tumor growth; the Transforming Growth Factor (TGF-beta) plays a significant role in the management of immunity. However, with the dysregulation of this tumor suppressing cytokine, TGF-Beta one is no longer an anti-migratory and anti-proliferative protein. Instead, negative regulation causes TGF-beta1 to serve as an oncogenic factor, promoting Metastasis, angiogenesis, and tumorigenesis. This article explores the effects of mutations on TGF-beta1 by comparing the different genetic codes of the TGF-beta superfamily to identify the main procedure of negative regulation. This article also reviews the range of influence the TGF-beta cytokines have in the tumor-microenvironment.