Siri Manthapuri

Differential expression of cytokines in male and female glioblastoma patients

Started July 2, 2022

Abstract or project description

In this project, Siri is examining copy number alterations of different cytokines in male and female glioblastoma patients. She is also studying if mRNA expression levels of those genes are different in those patients. Furthermore, Siri plans to look into whether those differences indicate distinct immune infiltration profiles in patients. Patient survival data will also be studied. Siri is expected to write a research paper based on those data.

A Brief Overview of Pathological Tau and Inhibitors and Modifiers of Tau Aggregation for Treatment of Tauopathies

Started Mar. 20, 2021

Abstract or project description

Tauopathies make up a significant portion of neurodegenerative diseases, affecting tens of millions of people. Tauopathies are defined by abnormal tau protein aggregation.  Current approaches to tauopathy inhibition and therapeutic development require an in-depth understanding of post-translational modifications and propagation of pathological tau. Research thus far has produced a variety of inhibiting and mitigating compounds to alleviate tau aggregation. These compounds employ distinct mechanisms, including: kinase-, enzyme-, and secretion-inhibition, direct aggregation inhibition, and upregulation of cellular degradation systems. Overall, the current progress and ongoing research in the development of tauopathy therapeutics has potential, while also highlighting some crucial unknowns in the field that warrant further investigation.