
Polygence Scholar2026

Saya Toth
Class of 2027
About
Projects
- "analysis on public H3K27M diffuse midline glioma (DMG) scRNA-seq data, stratified by anatomical location" with mentor Mathias (Working project)
Project Portfolio
analysis on public H3K27M diffuse midline glioma (DMG) scRNA-seq data, stratified by anatomical location
Started June 4, 2026
Abstract or project description
Research question Do tumor–microglia cell–cell communication networks differ between pontine and thalamic H3K27M-mutant diffuse midline gliomas (DMGs) in public scRNA-seq data?
Hypothesis (directional) H1: At least one ligand–receptor (L-R) pair in the malignant → microglia direction has a different per-sample communication probability between pontine and thalamic H3K27M DMG samples.
H0: No L-R pair differs between locations after multiple-testing correction.
