Class of 2024Sparta, New Jersey
AboutHello! My name is Sarah Weisbeck and my Polygence project is on CAR T-Cell Therapy as a form of cancer treatment. I chose to work on this project because I am interested in the medical field and biomedical sciences. After my project is complete, I would like share my findings with others.
- "What are the advancements and limitations of CAR T cell therapy in solid tumors?" with mentor Jessica (Sept. 15, 2023)
What are the advancements and limitations of CAR T cell therapy in solid tumors?
Started Feb. 16, 2023
Abstract or project description
Chimeric antigen receptor (CAR) T cell therapy is a type of immunotherapy that functions by targeting specific antigens on tumors. Six CAR T cell therapies for blood cancers have been approved by the Food and Drug Administration (FDA) since 2017, and now research moves forward to focus on solid tumors. Solid tumors require much more endurance from T cells due to their complexity, leading to additional barriers not faced in blood cancers. Many limitations surround CAR T cell therapy in solid tumors, including severe adverse events and the immunosuppressive tumor microenvironment. Recent research advancements have focused on logic gates, CAR T cells in combination with other therapies, and better targeting tumor cells as solutions to these limitations.