Mount Hebron High SchoolClass of 2022
- CDKN1C Hypermethylation Patterns in Human Breast Cancer with mentor Taylor (Sept. 7, 2021)
Sanjana's Symposium Presentation
CDKN1C Hypermethylation Patterns in Human Breast Cancer
Abstract or project description
CDKN1C (p57/KIP2), a tumor suppressor gene from the CIP/KIP protein family, regulates cell proliferation by inhibiting the Cyclin D1/CDK4 complex during the G1 phase of the cell cycle. The *CDKN1C* gene is part of a chromosomal region which is characteristically hypermethylated in various cancers, but the exact changes in methylation and their effects on breast cancer are unknown. This study utilizes computational tools to analyze the patterns of *CDKN1C*methylation in different stages of breast cancer.