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Polygence Scholar2021
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Sanjana Srimath

Mount Hebron High SchoolClass of 2022Ellicott City, Maryland



  • "CDKN1C Hypermethylation Patterns in Human Breast Cancer" with mentor Taylor (Sept. 7, 2021)

Sanjana's Symposium Presentation

Project Portfolio

CDKN1C Hypermethylation Patterns in Human Breast Cancer

Started June 21, 2021

Abstract or project description

CDKN1C (p57/KIP2), a tumor suppressor gene from the CIP/KIP protein family, regulates cell proliferation by inhibiting the Cyclin D1/CDK4 complex during the G1 phase of the cell cycle. The CDKN1C gene is part of a chromosomal region which is characteristically hypermethylated in various cancers, but the exact changes in methylation and their effects on breast cancer are unknown. This study utilizes computational tools to analyze the patterns of CDKN1Cmethylation in different stages of breast cancer.