Rachel Siu

The Role of Genetics in Depression and Its Implications for Individualized Treatment

Started Sept. 8, 2025

Abstract or project description

Depression is a mental health disorder characterized by prolonged sadness and anhedonia–the loss of enjoyment in previously enjoyable activities. An estimated 332 million people, or about 4% of the world population, are affected by depression. It is caused by a combination of genetic and environmental factors, and depending on an individual’s genetic predisposition, the associated risk may greatly vary. Prolonged periods of depressive episodes significantly impact the daily lives of those affected and can lead to self-harm or suicide. The most common forms of treatment are antidepressants and psychotherapy, but these vary based on the person affected. Despite decades of research on depression, there is still much unknown about the condition. This review explores the role of genetics in depression and how treatment options can vary based on individual genetic and physiological differences.

Cells Gone Rogue: Understanding the Biology of Cancer and potential treatments

Started Mar. 3, 2025

Abstract or project description

Cancer, one of the leading causes of death globally, can arise due to an organism’s inability to replicate its genomic DNA perfectly. But what occurs inside a cell to allow these errors in replication to occur? In this pod, students interested in medicine, biology, and genetics will gain a basic understanding of cancer biology; such as how intrinsic and extrinsic factors that cause damage DNA can lead to the development of cancer, different ways of treating cancer, and how cancer can become resistant to treatment and spread around the body. Each student will explore and write a short paper about a particular treatment method used to treat a cancer of their choosing, incorporating at least two primary research papers into their review. In addition to learning about basic cancer biology, students will learn the fundamentals of reading and writing research papers and communicating science to others.