Pranav Potluri

Genetic Vulnerability: PIK3CA Gene Dependency in HER2-Positive Breast Ductal Carcinoma

Started Apr. 19, 2022

Abstract or project description

In the medical world, a multitude of revolutionary technologies have been developed to improve the process of diagnosing and treating a patient. In the modern era, one of the most innovative developments is the use of CRISPR-Cas9, an enzyme that uses palindromic sequences of nucleotides to bind to and delete or edit DNA. Although heavily studied as a genetic engineering tool, this fascinating protein can also identify genetic targets to improve cancer therapy through CRISPR screening. CRISPR screening is an experimental approach that can identify genes that are responsible for a specific phenotype. This paper