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Polygence Scholar2022
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Mrinmayee Sama

American High SchoolClass of 2023Fremont, California


Hi! My name is Mrinmayee Sama and I am currently a senior at American High School in Fremont, California. I aspire to be a pediatric oncologist due to my passion for taking care of kids and helping patients. I want to major in biochemistry as I would like to see how biology meets chemistry on a cellular level. I am currently working on a paper which touches on cancer and how the p53 protein reacts with Mdm2 when cancer is present


  • "The dysregulation of Mdm2-mediated degradation of p53 causes cancer " with mentor Rebecca (Dec. 4, 2022)

Project Portfolio

The dysregulation of Mdm2-mediated degradation of p53 causes cancer

Started Apr. 17, 2022

Abstract or project description

The tumor-suppressor protein, p53, receives a multitude of inputs like DNA damage and growth signals to cause downstream effects like apoptosis, DNA repair, and inhibition of angiogenesis. Precise regulations are highly important to maintain regular healthy cells. In this paper, we will be looking at one of those regulation strategies: Mdm2 and the ubiquitin-mediated degradation of p53. When the balance of the Mdm2 and p53 is dysregulated, cancer is a common outcome. Mdm2 and p53 complex, when the balance is dysregulated, cancer is a very likely outcome. In this review, we will explore the mechanism of how this balance gets dysregulated through mutations and cellular stress. We will also highlight the types of cancer where Mdm2 and p53 dysregulation is common and current therapies that address this mechanism.