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Polygence Scholar2024
Medha Nalakonda's profile

Medha Nalakonda

Class of 2025San Jose, California


Hello, My name is Medha Nalakonda and I am a sophomore in high school. My Polygence project is on the topic of nanoscience and its applications in detection processes with the combination of artificial intelligence systems.


  • "How can nanoparticles enhance the abilities of antigen-presenting cells in immunotherapy?" with mentor Lucas (June 18, 2024)

Project Portfolio

How can nanoparticles enhance the abilities of antigen-presenting cells in immunotherapy?

Started May 4, 2023

Abstract or project description

Nanoparticles play a pivotal role in revolutionizing immunotherapy, particularly in targeting antigen-presenting cells(APCs) to induce a robust cell-mediated immune response. Certain examples of these cells include dendritic cells, macrophages, and B cells. APCs are crucial in initiating and regulating immune responses, and nanoparticles offer a sophisticated means to enhance their activation. The design of nanoparticles, including their materials, size, shape, and surface modifications, plays a crucial role in influencing the different characteristics of each APC. By tailoring these characteristics, researchers can optimize the interaction between nanoparticles and APCs, to result in the modulation of the immune response. For example, nanoparticles can be engineered to efficiently deliver antigens or therapeutic agents to APCs, enhancing antigen presentation and acting as a catalyst for the activation of T cells. This precise control over the immune system holds immense potential for developing targeted immunotherapies with enhanced efficacy and reduced side effects.