Gaithersburg High SchoolClass of 2023Gaithersburg, MD
- "Exploring Novel Combinatorial Therapies in Stomach/Gastric Cancer." with mentor Garrett (Sept. 29, 2022)
Exploring Novel Combinatorial Therapies in Stomach/Gastric Cancer.
Started May 27, 2022
Abstract or project description
Exploring Novel Combinatorial Therapies in Stomach Cancer I’m Hassanatu K Kamara and I'm doing cancer research. My cancer of interest is Gastric cancer in general because I don’t have a specific type. I want to Learn about how tumors are formed, the risks that come with this type of cancer, how it can be prevented and most importantly how it can be treated. Gastric cancer is a well-known, life threatening condition that is affecting many people all over the world. Today, gastric cancer represents one of the leading causes of death worldwide, but very little is known about the antiquity, epidemiology and evolution of cancer in past human populations. One of the mechanisms in which it develops is after many years of chronic H pylori infection, in a chronically inflamed stomach characterized by atrophic glands and expanded stroma. Thus, alterations in specific niches precede the activation of gastric stem cells and the initiation of cancer. It was first discovered in 2125 BC by the first researchers in the gastroenterological field during the 10th dynasty of the Pharaohs by Irynathty, the court physician. During the 20th century, thanks to the scientific and technological advances the causes of cancer were discovered and the role of the bacterium Helicobacter pylori has also been demonstrated. The risks of gastric cancer include Gastroesophageal reflux disease, Obesity, high diet in salty and smoked foods, low diet in fruits and vegetables, family history of stomach cancer, Infection with Helicobacter pylori, long-term stomach inflammation (gastritis), and Smoking. The risk of gastric cancer goes up as a person gets older, and it is more common in men than in women. It can be prevented by frequently checking your ulcers, cut down on smoked foods, quitting smoking, exercising, maintaining a healthy weight, considering genetic testing, and using aspiring frequently and wisely because aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can lower the risk for getting some kinds of stomach cancer. There are many ways of treating this type of cancer, but the famous ways are surgery, chemotherapy,immunotherapy,radiation, and multidrug treatment. I’m more interested in learning about multidrug treatment and radiation. People with stomach cancer usually receive external-beam radiation therapy, which is radiation given from a machine outside the body. Radiation therapy may be used before surgery to shrink the size of the tumor or after surgery to destroy any remaining cancer cells.