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Polygence Scholar2024
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Ellie Park

Class of 2025Scottsdale, Arizona

About

Hello !! My name is Ellie and my Polygence project is on the specific variants of the ABCC11 gene. I wanted to increase my knowledge, not only satisfying my own curiosity but bringing questions and solutions to the scientific world. Being a Korean American with a family history of breast cancer, ABCC11 was a gene that was able to connect the cultural world with the scientific. I hope that by the end of my research I can bring new information, questions, and solutions to the scientific world that can prove to be fruitful and promising to our society.

Projects

  • "The ABCC11 Gene and its marvelous SNP: Connecting Earwax, Sweat, and Breast Cancer" with mentor Grace (Working project)

Ellie's Symposium Presentation

Project Portfolio

The ABCC11 Gene and its marvelous SNP: Connecting Earwax, Sweat, and Breast Cancer

Started May 9, 2024

Portfolio item's cover image

Abstract or project description

Cancer has been a detrimental cause of death and a persistent global health issue for millennia. Breast cancer, in specific, has been one of the most prevalent types of cancer, especially in women. This paper presents the roles of a genetic mutation present within ABCC11, specifically the SNP rs17822931 538G>A, in breast cancer carcinogenesis, pre diagnosis, and possible treatment outcomes. While the ABCC11 protein functions as a transporter for specific molecules within cells, the genetic mutations, particularly the WT (wild-type) allele (538Gly), are linked to phenotypic expressions of wet earwax, axillary osmidrosis, and an increased risk of breast cancer incidence. While the WT (538Gly) allele is more frequent in African and Caucasian populations, the variant allele (538Arg) is more prevalent in the Eastern Asian population. With further research, the functions of the ABCC11 protein and the phenotypic expressions of ABCC11 may be utilized as a method for early genetic screening for breast cancer development and offers future therapeutic possibilities, improving breast cancer outcomes.