Class of 2024Sunnyvale, California
- "Resiniferatoxin: Mechanism in Treating Osteoarthritis Pain and Slowing Osteoarthritis Progression, Safety, and Efficacy" with mentor Andrew (Sept. 10, 2023)
Resiniferatoxin: Mechanism in Treating Osteoarthritis Pain and Slowing Osteoarthritis Progression, Safety, and Efficacy
Started June 15, 2023
Abstract or project description
Resiniferatoxin is a diterpene found in E. resinifera and E. poissonii, and is a more potent functional analog of capsaicin. Resiniferatoxin provides pain relief by binding as an agonist to transient vanilloid receptor 1 (TRPV1), a nociceptive ion channel. Resiniferatoxin targets the TRPV1 channel and activates it, allowing calcium cations to flow in and desensitize the TRPV1 receptors, which produces an analgesic effect. Resiniferatoxin was recently designated as a breakthrough therapy by the FDA for the treatment of the pain caused by knee osteoarthritis, a common degenerative joint disease caused by aging, joint injury, and obesity. Studies suggest that osteoarthritis is linked with chronic inflammation through a cycle of injury, inflammation, and repair. Multiple studies involving TRPV1 agonists have shown anti-inflammatory properties, presenting TRPV1 agonists as a potential inhibitor for the progression of osteoarthritis. This review highlights the mechanism of resiniferatoxin in the human body, especially in treating pain caused by knee osteoarthritis, and its efficacy compared to other TRPV1 agonists.