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Polygence Scholar2023
Anish Krishnan's profile

Anish Krishnan

Class of 2024Cupertino, California


Hello! My name is Anish Krishnan and my Polygence project is on how the structure of the brain and its parts relate to mental disorders and the formation of personality. I chose to work on this project because I've always been passionate about people and what they think, and I enjoy learning how their minds work and why they work that way. How that combines with the biological structure of the brain is a topic that I've explored before, and found very interesting, so I would like to explore that niche more in depth. Once I complete this project, I hope to publish a research paper on it, and hopefully even showcase it at at the Symposium.


  • "How are abnormalities in the prefrontal cortex associated with Antisocial Personality Disorder?" with mentor Elliot (Sept. 12, 2023)

Project Portfolio

How are abnormalities in the prefrontal cortex associated with Antisocial Personality Disorder?

Started June 4, 2023

Abstract or project description

Antisocial Personality Disorder, or ASPD, is a personality disorder that affects between 0.6 and 3.6% of adults. People with ASPD are impulsive, aggressive, and tend to lack empathy for others, often leading to violent tendencies and even criminal behavior. While there is a lack of knowledge of the specific cause of the disorder, many have researched and found that it can be linked to biological factors in the brain, with structural and functional irregularities having a strong connection to the disorder. By conducting a literature review, I draw attention to the association between ASPD and brain abnormalities, with a particular focus on the relation the prefrontal cortex has with the disorder. With this, I attempt to show a potential factor in the development of ASPD in order to better understand people with the disorder and potentially find a way to more effectively treat it.