Symposium

Of Rising ScholarsFall 2022

Angie will be presenting at The Symposium of Rising Scholars on Saturday, September 24th! To attend the event and see Angie's presentation,

Register here!
Go to Polygence Scholars page
Angie Cheng's cover illustration
Polygence Scholar2021
Angie Cheng's profile

Angie Cheng

Los Altos High SchoolClass of 2023Los Altos, California

About

Projects

  • "Biomimetic blood cell coated nanoparticles for improved site specificity and enhanced bioavailability" with mentor Henry (Aug. 21, 2022)

Project Portfolio

Biomimetic blood cell coated nanoparticles for improved site specificity and enhanced bioavailability

Started Feb. 28, 2022

Abstract or project description

Traditional nanotherapeutics encounter biological barriers such as macrophage mediated phagocytosis, which hinder persistent circulation and efficacious response. Phagocytes are capable of engulfing and absorbing foreign particles and cells in the body while avoiding clearance of “self” cells. Shielding nanotherapeutics with biomaterials derived from cell membranes of blood cells can enable escape of biometric nanoparticles from clearance by the immune system. Here, biomimetic shielding of nanoparticles with membrane signaling peptides is reviewed as a methodology to improve the efficacy and site specificity of nanoparticle mediated drug delivery.