Symposium

Of Rising Scholars

Spring 2024

Aldan will be presenting at The Symposium of Rising Scholars on Saturday, March 23rd! To attend the event and see Aldan's presentation.

Go to Polygence Scholars page
Aldan Joseph's cover illustration
Polygence Scholar2023
Aldan Joseph's profile

Aldan Joseph

Class of 2025San antonio, TX

About

Projects

  • "Early onset of Alzheimer's is on the rise - Evidence and Implications" with mentor Colwyn (Nov. 25, 2023)

Project Portfolio

Early onset of Alzheimer's is on the rise - Evidence and Implications

Started Jan. 20, 2023

Abstract or project description

The prevalence of early-onset Alzheimer's Disease (AD) and Major Depressive Disorder (MDD) has demonstrated an escalating trajectory. This warrants an investigation into their intricate connections. This review will assess the relationship among AD, MDD, and their associated medication, specifically Selective Serotonin Reuptake Inhibitors (SSRIs). The overarching hypothesis suggests that diet significantly contributes to depression by modulating tryptophan metabolism, and SSRIs can significantly stunt AD progression. Therefore, this review will examine three aspects: the biochemistry of depression and how it relates to the progression of AD; how diet is linked to MDD and whether this is predominant in a younger age range; and the potential effectiveness of the SSRIs fluoxetine (FLX) and citalopram as a treatment to inhibit AD pathology.