Symposium

Of Rising Scholars

Spring 2024

Aisha will be presenting at The Symposium of Rising Scholars on Saturday, March 23rd! To attend the event and see Aisha's presentation.

Go to Polygence Scholars page
Aisha Weththasingha's cover illustration
Polygence Scholar2024
Aisha Weththasingha's profile

Aisha Weththasingha

Class of 2026

About

Projects

  • "How can using monoclonal antibodies to prevent CCL22 from binding to its receptor, CCR4, be a more effective way of preventing inflammation or lesional skin in those with atopic dermatitis?" with mentor Micayla (Working project)

Project Portfolio

How can using monoclonal antibodies to prevent CCL22 from binding to its receptor, CCR4, be a more effective way of preventing inflammation or lesional skin in those with atopic dermatitis?

Started Oct. 23, 2023

Abstract or project description

This paper will start by explicating how inflammation occurs in atopic dermatitis (AD), setting up the reasoning behind what monoclonal antibodies in current AD treatments target and why they work. After explaining how inflammation and lesional skin occurs in patients with atopic dermatitis, the paper will begin explaining how monoclonal antibodies work and are used in existing treatments to prevent inflammation in those with atopic dermatitis. After explaining how and why the monoclonal antibodies work in current treatments, the paper will turn to diving deeper into explaining the role of CCL22 and CCR4 in inflammation in atopic dermatitis and why they are part of the issue. To wrap up the information provided, the paper will theorize how using monoclonal antibodies designed to prevent CCL22 from binding to CCR4 could be an additional approach to preventing lesional skin.