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Polygence Scholar2022
Adhiraj Mantan's profile

Adhiraj Mantan

Coppell HighschoolClass of 2024Irving, Texas



  • "Publish an article: Kickstart your career as a scholar learning the neuroscience of how your brain interprets sound" with mentor Rahul (Sept. 10, 2023)
  • "Pathophysiology of Cushing's Disease" with mentor Brendan (Oct. 28, 2022)

Adhiraj's Symposium Presentation

Project Portfolio

Publish an article: Kickstart your career as a scholar learning the neuroscience of how your brain interprets sound

Started Aug. 1, 2023

Portfolio item's cover image

Abstract or project description

The brain is incredible and complex and the source of much scientific research around the world. In this pod, you’ll focus on how our brains allow us to take unassuming sound waves and enable us to enjoy music, learn a new language, or recognize danger. Through this fascinating process, students will learn about the research process, the brain regions, how the brain regions cooperate to interpret sensory information, and how those individual actions culminate into the actions we take every day but may take for granted.

Project Portfolio

Pathophysiology of Cushing's Disease

Started July 6, 2022

Abstract or project description

The endocrine system is key in maintaining the homeostasis of the body, and involves various feedback loops within endocrine organs. Additionally, endocrine disorders affect a significant portion of the global population and are a common reason to seek medical treatment. Among endocrine disorders, Cushing's disease is an interesting example and results in disruption of the hypothalamic-pituitary-adrenal axis. In true (endogenous) Cushing's syndrome, these symptoms are due to the presence of a tumor secreting one of the hormones in the HPA axis. However, very similar findings are seen in immunosuppressed persons due to the introduction of exogenous steroids as treatment which disrupt the HPA axis in a similar manner. This blog series will provide an overview of the endocrine system, particularly the HPA axis, introduce Cushing's disease and relevant epidemiology, molecular mechanisms, and treatments, as well as draw parallels to the treatment-induced hypercortisol state seen in immunosuppressed patients.