Abhi Boyapati

Investigating the Linkage Between Cardiovascular Disease and Lupus

Started Aug. 3, 2023

Abstract or project description

This research paper investigates the intricate linkages between four types of lupus—systemic lupus erythematosus (SLE), cutaneous lupus, drug-induced lupus, and neonatal lupus—and cardiovascular disease (CVD). Lupus, an autoimmune disorder with diverse symptoms, is associated with an increased risk of cardiovascular complications, including atherosclerosis, myocarditis, and vasculitis. A comprehensive review of current literature was conducted to explore the connections between different lupus types and cardiovascular diseases, focusing on mechanisms such as immune dysregulation, inflammation, and endothelial dysfunction. The study revealed significant correlations between lupus and various cardiovascular diseases. Patients with lupus exhibited higher incidences of atherosclerosis, myocarditis, and vasculitis compared to the general population. Mechanistic insights highlighted the roles of immune system abnormalities, chronic inflammation, and endothelial dysfunction in elevating cardiovascular risk among lupus patients. Understanding the interplay between lupus and cardiovascular diseases provides opportunities for targeted therapeutic interventions and personalized medical approaches. This exploration underscores the need for heightened cardiovascular monitoring and tailored treatments in lupus patients to mitigate their increased cardiovascular risk.