Aalya Arora

Nanocarrier–Stem Cell Synergy in Alzheimer’s Disease: Overcoming the Blood–Brain Barrier Through Precision Nanomedicine

Started Aug. 13, 2025

Abstract or project description

Alzheimer’s disease remains a leading cause of dementia worldwide, with no widely effective disease-modifying therapies despite decades of research. A central limitation in therapeutic development is the restrictive nature of the Blood–Brain Barrier (BBB), which prevents the efficient delivery of biologics, including stem-cell-based interventions. Recent advances in nanotechnology and regenerative medicine suggest that combining engineered nanocarriers with stem cell therapies may overcome these translational barriers. This review argues that a combinatorial nanocarrier–stem cell approach produces synergistic improvements in BBB penetration, cellular survival, targeted trophic delivery, and real-time tracking, representing the most promising near-term pathway for disease-modifying Alzheimer’s therapies. Supporting evidence is drawn from mechanistic BBB studies, nanocarrier delivery research, stem cell clinical trials, and emerging work in exosome-mediated transport and theranostics.