Understanding the role of MYC deregulation in breast cancer and leukemia and current challenges in targeting MYC oncogene
Project by Polygence alum Siya
Project's result
The outcome of this project was the identification of emerging therapeutic strategies for targeting MYC's role in breast cancer and leukemia, along with the parallel challenges that complicate them.
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Summary
This paper explores the role of MYC deregulation in two major types of cancer: breast cancer and leukemia. MYC is an oncogene that plays a crucial role in regulating cell growth, differentiation, and transcription. When MYC is overexpressed or underexpressed, it leads to uncontrolled cell proliferation, contributing to the development and progression of cancer. Despite the critical role MYC plays in these cancers, targeting the MYC oncogene for therapeutic purposes has proven to be challenging due to its unique structure and complex interactions with other proteins. Various strategies for targeting MYC will be examined including new compounds that indirectly disrupt MYC’s stability and interactions. By understanding the challenges and potential strategies for targeting MYC, this review aims to provide insights into how we can improve treatment outcomes for patients with MYC-driven cancers, offering hope for future therapeutic developments.
Sabin
Polygence mentor
PhD Doctor of Philosophy
Subjects
Neuroscience, Biology, Medicine
Expertise
Neuroscience, Genetics, Genomics, Epigenetics, Biochemistry, Genomics, Cancer biology
Check out their profile
Siya
Student
Graduation Year
2026
Project review
“Mentor guidance, support met my expectations”
About my mentor
“She was helpful in narrowing down ideas, structuring my paper, and communicating expectations.”