Deconvoluting the Gut-Mind Interactome: How Structural and Functional Disruptions to the Gastrointestinal Tract Seed Neurocognitive Dysregulation

This comprehensive study aims to understand the gut-brain axis, elucidating its critical role in various physiological functions, including absorption, immunity, and homeostasis, and its relation to neurocognitive dysregulation. We reveal how gut physiology serves as a vital feedback system, with disruptions potentially leading to adverse effects on neural and mood phenotypes, including psychological dysregulation. This research provides a deeper understanding of the intertwined nature of the gut microbiome and cognitive function, exposing an extraordinary level of interconnectivity across human physiological systems and its implications for cognition. Notably, it underscores potential common genetic underpinnings between gastrointestinal and psychiatric disorders, indicating a link between poor gut health and mental disorders such as anxiety, depression, and cognitive decline. Our findings highlight the critical role that the structural and functional characteristics of the gastrointestinal tract play in maintaining mental well-being. Specifically, we focused on the impact of alterations due to Helicobacter Pylori, celiac disease, and short gut syndrome. These insights highlight the importance of advancing our knowledge of the gut-brain axis and the need for future research. This includes exploring the effects of diet on gut health, developing innovative treatment strategies, and investigating the potential of emerging technologies in the pursuit of more effective and personalized interventions for these complex conditions. We hope such endeavors will significantly enhance the quality of life for individuals affected by these conditions and promote overall mental well-being.