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Luke

PhD Doctor of Philosophy

Expertise
Immunology, virology, genetic engineering

Project ideas

Project ideas are meant to help inspire student thinking about their own project. Students are in the driver seat of their research and are free to use any or none of the ideas shared by their mentors.

Write a review article about your immune cell of choice and how it behaves during infection or against cancer.

Choose an important immune cell of choice such as a Natural Killer cell, T cell, B cell or dendritic cell. Together we will describe the journey this cell takes on its infection or tumor fighting mission. We will use other review and primary research articles to understand this process. We will then write an article outlining this process which will include graphics we can create using a free software that allows the generation of powerful and detailed biological processes.

Bigger is not always better... When it comes to manufacturing for cell therapies against cancer.

Here we will dive into the difficult process known as upscaling to create cell therapies that can be used to fight cancer. Cell therapies known as "immunotherapies" are therapeutics in which a patients cancer fighting T or NK cells are taken from their blood, enhanced and expanded using a number of techniques and then re-infused into the patient in order to target their cancer. The process from doing this in a small scale to a large scale of millions to billions of engineered cells has a lot of challenges. In this project we will describe some of the challenges that are faced by manufacturing companies and we will propose new and alternative ideas to help circumvent the problem of upscaling. Perfect for anyone interested in bioengineering or related fields.

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