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Jacqueline H

- Research Program Mentor

PhD at Brown University

Expertise

Immunology, Ecology, Behavioral Sciences, Neuroimmunology, neurodegenerative disease, philosophy of immunology

Bio

As an ecologist and immunologist by training, one of the most important inquiries of modern biomedical science that endlessly fuels my curiosity is how physiological systems influence one another. Outside of my research interests, I have a strong passion for building a supportive graduate school community through peer mentorship, collecting books, and sewing clothes, curtains, costumes, and hanging with friends. I'm from San Francisco and have spent a lot of time thinking about philosophy, my favorite question being "why?"

Project ideas

Project ideas are meant to help inspire student thinking about their own project. Students are in the driver seat of their research and are free to use any or none of the ideas shared by their mentors.

Research Perspective Paper

Review of current literature regarding neuroimmunology, neurobiology and behavior, neurodegeneration, or aging, or another field of research if none of the above interest you. You will then search for papers that shifted how the field shifted with a focus on the most current opposed hypothesis and theories. You will then assess the quality of the data, arguments, rationale and models and make an argument for your own perspective or for one of the others. A perspective paper is typically not long (8-12 pages), but dense with material and requires a true dedication to reading the materials and a creative mindset to make a case for which hypothesis you deem worthy of further pursuit! The outcomes will be production of a paper which can be submitted as an article and presented at a symposium. Additionally knowledge that can be gained is understanding the current state of the field, and the current discussions regarding how novel technologies can result in interesting discovery.

Sci Comm

This project would involve a skill that most folks struggle with in science: communicating results and their relevance clearly, accurately, succinctly, and most importantly in an engaging manner. While this is helpful for the lay audience, it is also helpful for many researchers because of the increasing value of an ecological perspective in biomedical research, requiring a greater breadth in knowledge. Thus this project would require reading literature relevant to a scientific topic I have knowledge in (immunology, neurobiology, neurodegeneration, behavior, but more could be discussed) or about some aspect of philosophy of science,(some examples would be progress through history, or competing philosophies and how they are now represented in current fields I mentioned above). The project product will be a short zine/pamphlet/poster that will display the information that you find most interesting or crucial for the intended audience with the aesthetics you think would be most fitting for the topic and the most engaging. From this project you will gain skills in presentation of ideas and data which is a very important aspect in science. This will involve finding a source of publicly available data regarding the topic of your choice, and determining how to best begin analysis of data using excel or google spreadsheets to determine the question of interest based on simple graphical outputs. Once a question based on inferred patterns is determined from a first pass of simple correlative analysis, this project will next determine what platform (magazine article, online resource which may be shared with other, or applied to writing a paper from findings) would be best suited for questions and data visualization best practices. Once platform is determined, the next step will be to explore various methods of interactive and effective modalities and techniques used in both STEM papers and presentations for conferences. Additionally learning data visualization techniques lends to capacity to recognize patterns and link those patterns to questions that may be relevant to ask if the data was collected by you, as these methods are used for visual learners to analyze data sets in academia. Outcomes include: A scientific contribution to open source data banks

Interview a scientist!

We will find a scientist or group of scientists in a field of your choice in academia in a field that you are interested in that I have expertise in: Artificial Intelligence, Philosophy of Science, Cancer Immunology, Clinical Immunology, Clinical oncology, Ecology, Computational Science, Neuroimmunology, neurodegeneration, aging, immunology, behavior and interview them for a podcast/youtube/vimeo etc. educational video. Project learning opportunities would include: learning how to find scientists to connect to through networking, determining the scientists you'd think would be helpful to your research, reading literature that would bolster these experiences to provide an opportunity to learn how to formulate questions to ask of the scientific community experts, learning how to conducting/editing the interview, and consideration of how to portray to the audience your vision of what information you think is most exciting for the intended audience to learn from this conversation! This will in here is an example: https://youtu.be/1EfOWIvv0Jc?si=VjiE_72dpwIdcr6k

Bioinformatics extension applications of diagnostics and treatment regimens.

For this project open access data banks would be used to evaluate quantitative patterns across datasets. A project in this lane would entail learning key skills for the evolution of AI/Agenic AI, and LLM. Creativity is a helpful skill that can be honed and used in the process of developing an algorithm or pipeline that predicts stratification across diseases or other demographic areas of interest. Additional skills learned could be learning coding architecture in conjunction with how to use modern toolsets currently discussed at the National Level.

Wet Lab at Home

This project would include observational data based on in house or field experiments. This could range anywhere from how to measure a food type and how it is stored, to the growth of bacteria from a phone. Typically this type of project requires strong fortitude and learning extensively about experimental design processes focusing on materials and methods. Additionally quantification and analysis whether that be image analysis using tools like ImageJ or Matlab are skills that will come from this type of project. Additionally understanding the basics of scientific experimentation on limited resources and creative design are the learning goals and publishable outcomes for those papers requiring wet lab experience.

Coding skills

Matlab, JMP, Python, R

Languages I know

Italian-proficient

Teaching experience

Since earning my PhD in Pathobiology from Brown, I have currrently been focused on curriculum development ideation in collaboration with the National Science Foundation to begin to find ways to teach immunology across the country adapting to modern findings. My focus here is on rhetorical device use, specifically, metaphors and analogy as a mechanism to use our unique experiential knowledge base to bypass the jargon of immunology and facilitate learning the similars from the dissimilars underlying fundamental immune processes. As a graduate trainee, I aided in teaching a laboratory based microbiology course at Brown to introduces role of microbes in our understanding of biology at the molecular level in the context of infectious disease, public health, genetics, biotechnology, and biogeochemical conditions involving basic microbiological techniques leading to demonstrative conclusions about the external world by observing and evaluating different object classifying phenotypes from microbial growth on plates. I also presented regular review lectures and question sessions on class materials to aid in preparation for exams. Here I had the opportunity to serve as a scribe for students through student accessibility services, assessed unique laboratory reports from weekly experiments based on rationale and documentation of purpose, background, hypothesis, methodology performed, results and discussion. I spearheaded the creation of a structured peer mentorship program focused on promoting and improving graduate student well-being. Our mission is to foster supportive relationships with fellow graduate students through community-building activities, regular communication, and personalized mentorship. This mentorship involves steering new incoming students in the direction most suited for their interests and help guide them through the first steps of intensive independent research. This involves regular meetings to determine their goals and maintaining solid network of people who can assist in answering questions and perhaps offering shared resources to give the mentee the greatest chance in succeeding in their endeavors. Along with starting this peer mentorship program I now serve as a Pathobiology program peer liaison to steer professional development avenues working with the directors.

Credentials

Work experience

Brown University, Tatar & Kaun Lab,Lefort Lab (2017 - 2024)
PhD
UCSF, Bluestone Lab (2013 - 2017)
Research Associate
UC Berkeley, Rosenblum Lab (2011 - 2013)
Research Associate/Undergraduate Research Assistant
UC-Berkeley, Raulet Lab (2011 - 2013)
Laboratory Assistant

Education

University of California Berkeley (UC Berkeley)
BS Bachelor of Science (2013)
Ecology and Evolution
Brown University
PhD Doctor of Philosophy (2024)
Pathology, Neuroimmunology, immunology, myeloid progenitor engraftment, cancer, neurodegeneration, genetics, behavior

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