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Matthew T

- Research Program Mentor

PhD at Johns Hopkins University


Medical Imaging, Medical Physics, Machine Learning, Medical Image Analysis/Processing, Artificial Intelligence


I am an Instructor of Radiology at Harvard Medical School specializing in model-based tomographic reconstruction algorithms and statistical machine learning models for CT imaging applications. My research interests include using physics simulations for design optimization of CT imaging systems. I am also investigating diffusion models for learning prior information from large datasets for the purpose of improving image quality in medical images.

Project ideas

Project ideas are meant to help inspire student thinking about their own project. Students are in the driver seat of their research and are free to use any or none of the ideas shared by their mentors.

Diffusion Models for Medical Image Reconstruction or Restoration

Diffusion models are able to generate samples of high-quality medical images from low-quality measurements. This can apply to many different modalities or medical imaging systems. The goal of this project would be to use any dataset of high-quality medical images together with simulations of low quality measurements (e.g. noise or blur) for supervised learning of conditional diffusion models for medical image reconstruction. I can provide code examples of diffusion models that can be adapted for any medical image dataset the Polygence student is interested in exploring.

Project 2

Coding skills

Python, Pytorch, Tensorflow

Languages I know

Beginner Spanish, Beginner Russian

Teaching experience

I have ten years of experience as a part-time tutor, six years of experience as an undergraduate-level teaching assistant for engineering courses in computer programming, imaging physics laboratory, linear signals and systems, introduction to data science and machine learning. I also designed and taught for four years a college graduate-level course called "Statistical Foundations of Machine Learning". As an undergraduate and graduate researcher, I also have six years of experience mentoring young scientists and engineers. I have served as a peer research mentor to 4 high school students, 5 undergraduate research assistants, and 6 Polygence high-school students.


Work experience

Massachusetts General Hospital / Harvard Medical School (2023 - Current)
Instructor of Radiology
Johns Hopkins University (2018 - 2023)
Graduate Research Assistant (Ph.D. Student)
Photo Diagnostic Systems, Inc. (2017 - 2018)
Imaging Engineer
Northeastern University (2013 - 2017)
Teaching Assistant


Northeastern University
BS Bachelor of Science (2017)
Electrical Engineering and Physics
Johns Hopkins University
PhD Doctor of Philosophy
Biomedical Engineering

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