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Jen H

- Research Program Mentor

PhD Doctor of Philosophy candidate

Expertise

Neuroscience, psychedelic neuroscience, psychedelic biology, genetics and gene technologies, biology, neuroimaging

Project ideas

Project ideas are meant to help inspire student thinking about their own project. Students are in the driver seat of their research and are free to use any or none of the ideas shared by their mentors.

Human Gene Editing and its therapeutic applications

In this project, you will investigate the history of therapeutic human gene editing, what therapeutic gene technologies are available or are currently being developed, and what conditions these tools are being used for. You may choose to focus more broadly on the history and current status of human gene editing tools and therapy, or focus more closely on a specific gene/condition pair that has been or could be explored for gene therapy (e.g. sickle cell disease, cystic fibrosis). You may choose to write a literature review paper, write a blog post, or create a podcast outlining the relevant literature and current state of genetic therapeutic technologies... or, you could come up with another presentation method for displaying what you have learned! There are no solid pre-requisites for this project, though highschool level biology would be useful; my philosophy is to meet people where they are at, and modify the project according to their interests and skillset.

How do 5HT2a receptor mutations impact psychedelic subjective effects?

Classical psychedelics bind and exert their subjective effects through the 5HT2a receptor, which is densely expressed in prefrontal cortex and visual cortex. There are several relatively common 5-HT2a receptor polymorphisms in the human population. Little is known about how these polymorphisms affect the subjective effects (visual or cognitive) induced by psychedelics, which are relevant to their therapeutic potential. In this project, you could: 1) conduct a literature review on psychedelic subjective effects and current research into their neurobiological mechanism of action 2) propose an experiment that could help further our knowledge on how genetic mutations could affect the psychedelic experience, and ultimately psychedelic medicine There are no solid pre-requisites for this project. Ultimately we can work together to tailor this project to your experience and your goals!

Coding skills

Introductory python and matlab skills

Interested in working with expert mentors like Jen?

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