Reuben D
- Research Program Mentor
PhD at Brigham Young University
Expertise
Organic Chemistry, Cancer Biology and Therapeutics, Drug Discovery & Development, Biochemistry, Gene Therapy, Oligonucleotides, Nuclear Medicince
Bio
I am a Research Scientist at Purdue University. I research and supervise the investigation of diseases of the human body and how they can be understood and treated. I have a Bachelors in Chemistry with a Minor if Biology. My PhD is in Medicinal Chemistry, which focuses on the design and development of drug therapies for diseases of the human body. I was then a Postdoctoral Associate at Purdue University. The therapeutic areas of my research include immunology, radiotherapy, CAR-T cell therapy, genetics, antivirals, antibacterials, antiparasitics and . The diseases currently being investigated are blood and solid tumors, RSV, Influence, Malaria, Sickle Cell Disease, Multiple Myeloma, targeted immune cell switches and targeted radiotherapies. When I am not at work, I like to build Legos, hike with my dog or go to the gym!Project ideas
Project ideas are meant to help inspire student thinking about their own project. Students are in the driver seat of their research and are free to use any or none of the ideas shared by their mentors.
Synthesis and biological evaluation of novel pyrazolo[1,5-a]pyrimidines: Discovery of a selective inhibitor of JAK1 JH2 pseudokinase and VPS34
A series of novel 3,6-di-substituted or 3-substituted pyrazolo[1,5-a]pyrimidines were prepared via a microwave-assisted approach that generated a broad array of derivatives in good yields (20–93%, ave. = 59%). The straightforward synthesis involved sequential treatment of commercially-available acetonitrile derivatives. Importantly, a simple yet novel compound was equipotent with the more synthetically challenging 3,6-disubstituted derivatives and exhibited a promising and unique selectivity profile when screened against a panel consisting of 403 protein kinases.
Languages I know
Malay, Indonesian - pROFICIENTTeaching experience
I am a Researcher at Purdue University. I currently mentor 5 undergraduates who are part of my team researching the development of therapeutics against Cancers, Viruses and Blood Related Disorders. Prior to this position, I was a teaching assistant and co-teacher for General Chemistry, Organic Chemistry, Biochemistry and Immunology courses throughout my PhD program. During that time, I also privately tutored college students in Organic Chemistry. I have tutored over 10 students over the timeline described above.Credentials
Work experience
Brigham Young University (2017 - 2022)
Graduate ResearcherSimmons Center for Cancer Research (2019 - 2020)
Research FellowPurdue University Institute for Drug Discovery (2022 - Current)
Post-Doctoral AssociatePurdue University (2024 - Current)
ResearcherEducation
National University of Malaysia
BS Bachelor of Science (2017)
ChemistryBrigham Young University
PhD Doctor of Philosophy (2022)
Medicinal Chemistry (Oncology)