Karen W
- Research Program Mentor
PhD Doctor of Philosophy
Expertise
Human genetics, genomics, bioinformatics, DNA sequencing
Project ideas
1. Introduction to next-generation sequencing (NGS) technologies:
We will dive into different sequencing technologies and learn how they revolutionize our understanding of the human genome. We will also analyze publicly available datasets to learn how real world scientists use sequencing to interrogate different parts of the human genome. For more advanced students, we can develop innovative computational methods to tackle some of the complex regions that are inaccessible by typical sequencing methods.
2. Precision Medicine:
As the cost of DNA sequencing plummets, it is now possible to implement high throughput sequencing in genomic medicine. In this project, we will analyze simulated patient sequencing data and do some detective work to find out his/her genetic diagnosis! We will design a computational pipeline and package off-the-shelf algorithms to identify genetic mutation(s) underlying different diseases.