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Xanne

PhD Doctor of Philosophy candidate

Expertise
Immunology, brain tumor; T cell exhaustion; immunotherary; clinical trials; CRISPR technology, gene therapy, immune cell recovery following bone marrow transplant

Project ideas

Project ideas are meant to help inspire student thinking about their own project. Students are in the driver seat of their research and are free to use any or none of the ideas shared by their mentors.

Understanding T cell exhaustion in cancer

The immune system is very good at detecting invaders (bacteria, viruses, parasites). Over the last couple of years, we have also learned that the immune system provides an important protection against the development of cancer. Unfortunately, sometimes the immune system is unable to completely destroy a tumor. When this happens, the immune system will be continuously activated and this results in an "exhausted" cell. This exhausted cell is less capable to destroying tumor cells, allowing the tumor to grow and spread.

Gene editing as a treatment for sickle cell disease

Sickle cell anemia is a debilitating disease that causes patients excruciating pain, among many other symptoms. Patients with sickle cell disease often have shorter life spans than healthy people. Interestingly, sickle cell anemia is caused by a single nucleotide mutation in the DNA. This has led researchers to try to cure the disease by fixing the mutation on a genetic level using a relatively new technique called CRISPR.

Coding skills

limited R

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