PhD Doctor of Philosophy candidate
Universal tools: Understanding the role of Transcription Factors in Genome maintanance
Transcription factors (TFs) are key proteins and gene regulators which play diverse and important roles in regulating expression of genes within cells. While there are some unique TFs which play specific and isolated roles, many TFs are used and reused in unique and common combinations to produce a specific cell type identity, cell activation as well as participate in important key steps during development. A research paper on one such set of common TFs like P53 and MYC in cancer, or OCT4 and SOX2 in stem cells, would not only introduce the important of these universal protein tools but also demonstrate how combinatorics is central to understand how universal tools are used to build unique cell identities from all the genetic info stored in our genomes.