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Leon T

- Research Program Mentor

PhD Doctor of Philosophy


neurodegeneration, lysosomal biology, neuroscience, RNA-sequencing

Project ideas

Project ideas are meant to help inspire student thinking about their own project. Students are in the driver seat of their research and are free to use any or none of the ideas shared by their mentors.

Identifying novel strategies to treating neurodegenerative disorders

In recent years, many groups have performed large-scale functional genomics screens to identify target genes that can influence the cellular phenotypes thought to be central to neurodegenerative diseases. The results of many of these screens are publicly available. This project would involve 1) determining which cellular phenotypes would be of highest interest to target for a specific neurodegenerative disease; 2) mining the publicly available datasets to create a short list of candidate target genes; 3) reading through literature about candidate targets to prioritize specific ones based on specificity; 4) developing a therapeutic strategy to target the specific molecule of interest.

Coding skills


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