Leon T
- Research Program Mentor
PhD Doctor of Philosophy
Expertise
neurodegeneration, lysosomal biology, neuroscience, RNA-sequencing
Project ideas
Identifying novel strategies to treating neurodegenerative disorders
In recent years, many groups have performed large-scale functional genomics screens to identify target genes that can influence the cellular phenotypes thought to be central to neurodegenerative diseases. The results of many of these screens are publicly available. This project would involve 1) determining which cellular phenotypes would be of highest interest to target for a specific neurodegenerative disease; 2) mining the publicly available datasets to create a short list of candidate target genes; 3) reading through literature about candidate targets to prioritize specific ones based on specificity; 4) developing a therapeutic strategy to target the specific molecule of interest.