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Polygence Scholar2021
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Sai Sruthi Mopuri

Shishya BEML Public SchoolClass of 2023Bengaluru, Karnataka



  • "Genetic Engineering as an effective Cancer Therapy: A focus on CRISPR" with mentor Jose (Mar. 25, 2022)

Project Portfolio

Genetic Engineering as an effective Cancer Therapy: A focus on CRISPR

Started Oct. 24, 2021

Abstract or project description

Genetic engineering is the direct manipulation of an organism's genetic material . Modifications span from simple single nucleotide switches to the transfer of genes across species, to produce a desired characteristic. It has been promising for its precision, accuracy and potential to treat lethal diseases such as cancer. The most striking application of genetic engineering is for cancer pathologies. Through this review, we aim to focus on genetic tool Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and endonuclease Cas9 as cancer therapy, with special attention to highly metastatic BRCA1 Breast cancer (Triple Negative Breast Cancer), Glioblastoma, and Acute Myeloid Leukemia. CRISPR Cas9 seems very promising as a targeted therapeutic intervention-by targeting a group of proteins and genes that support cancer cell functions like metastasis, angiogenesis and rapid proliferation or another way is to target a group of healthy cells that are indirectly supporting cancer cell functioning. Targeted therapies help treat cancer without damaging healthy cells. Correcting the faulty genes using the complimentary CRISPR sequence can decrease or prevent cancer mortality and remission. There is a lot of study going on in this field, but we still are a long way from realizing the complete potential of CRISPR, for which we require more research. Hence, the benefit of this research is twofold- to understand cancer mechanisms and CRISPR mechanisms better, and to reduce treatment costs. Genetic engineering proves to be the best-targeted therapy for cancer and in this paper, we shall delve into its subsets CRISPR, and elucidate briefly on Immunotherapy, Nanostring Technology, and mRNA therapy and how these work harmoniously to revolutionize targeted therapy for cancer.